Herbal Ingredient Citrus Aurantium Extract 90% diosmin hesperidin
1.Sources and Habitation
Diosmin is a chemical found in citrus fruits and Scrophularia
nodosa, it is also a semisynthetic drug (modified hesperidin), a
member of the flavonoid family.
It is an oral phlebotropic drug used in the treatment of venous
disease, i.e., chronic venous insufficiency (CVI) and hemorrhoidal
disease (HD), in acute or chronic hemorrhoids, in place of rubber-band ligation,
in combination with fiber supplement, or as an adjuvant therapy to
hemorrhoidectomy, in order to reduce secondary bleeding. To control
internal symptoms of hemorrhoids (piles), it is used with hesperidin. Clinical studies have been inconclusive
and no review articles on its use in vascular disease have been
Diosimin has vitamin P sample effect, can reduce the permeability
of blood vessle brittleness and abnormal, and used in the adjuvant
treatment of prevention and control of high blood pressure and
hardening of the arteries, and also used in the treatment of blood
caplliary brittleness , in which had a better effection than rutin,
hesperidin, and has the characteristics of low toxicity.
2, Descriptions and Specifications of Product
Plant original: Scrophularia nodosa.
Specifications: 98.0% Diosmin Test by HPLC
Molecular Formula: C28H32O15
Molecular Mass: 608.54
CAS NO: 520-27-4
Main Functions and uses:
1,Diosmin is an anti-inflammatory and a flavonoid glycoside that
reduces venous hyperpressure.
2,Diosmin also reduces capillary hyperpermeability and expression
of endothelial adhesion molecules (ICAM1, VCAM1). Diosmin
effectively inhibits the P-glycoprotein (Pgp)-mediated efflux in
3,Diosmin is currently a prescription medication in some European
countries, and is sold as a nutritional supplement in the United
States and the rest of Europe.
4,Diosmin is used for treating various disorders of blood vessels
including hemorrhoids, varicose veins, poor circulation in the legs
(venous stasis),and bleeding (hemorrhage) in the eye or gums. It is also used to
treat swelling of the arms (lymphedema) following breast cancer
surgery, and to protect against livertoxicity. It is often taken in combination with hesperidin, another
Caution needed for pregnant and breastfeeding women. Side-effects:
Stomach and abdominal pain, diarrhea, and headach
The recommended dose is 1350 mg of diosmin plus 150 mg of
hesperidin twice daily for 4 days followed by 900 mg of diosmin and
100 mg of hesperidin twice daily for 3 days.
The Information had not been evaluated by the Food and Drug
Administration, only for reference
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