High Quality 99% purity orlistat powder CAS:96829-58-2
for weight loss
Orlistat is currently the best-selling weight loss products.
Orlistat is a potent and long-acting specific inhibitor of
gastrointestinal lipase, by directly blocking the body's absorption
of fat in the food intake of energy consumption and fat than once,
natural reduction of body fat, so as to achieve the purpose of
weight loss. It is safe to lose weight, the active ingredient does
not enter the blood circulation, do not act on the central nervous
system, with fewer side effects, no dizziness, palpitation,
insomnia, dry mouth, and so on.
Orlistat (also known as tetrahydrolipstatin) is a drug designed to treat obesity. It is marketed as a prescription drug under the trade name Xenical by Roche in most countries, and is sold over-the-counter as Alli by GlaxoSmithKline in the United Kingdom and the United States. Its primary function is preventing the absorption of fats from
the human diet by acting as a lipase inhibitor, thereby reducing caloric intake. It is intended for use in conjunction with a healthcare
provider-supervised reduced-calorie diet.
Orlistat is the saturated derivative of lipstatin, a potent natural inhibitor of pancreatic lipases isolated from the bacterium Streptomyces toxytricini. However, due to its relative simplicity and stability, orlistat
was chosen over lipstatin for development as an anti-obesity drug.
The effectiveness of orlistat in promoting weight loss is definite, though modest. Pooled data from clinical trialssuggest that people given orlistat in addition to lifestyle
modifications, such as diet and exercise, lose about 2–3 kilograms
(4.4–6.6 lb) more than those not taking the drug over the course of
a year. Orlistat also modestly reduces blood pressure, and appears to prevent the onset of type 2 diabetes, whether due to weight loss itself or to other effects; in a large
randomized controlled trial, orlistat was found to reduce the incidence of diabetes by nearly
40% in obese people.
|Appearance||White fine powder|
|Specific Rotation||-48° ~ -51.0°(on the anhydrous, solvent-free basis)|
|Identification||A.HPLC: The retention time of the major peak of the sample solution
corresponds to that of the standard solution.|
|B.IR: The IR spectrum of sample is consistent to the reference|
|Total impurity||Not more than 1.0%|
|Related Compound A||Not more than 0.2%|
|Related Compound B||Not more than 0.05%|
|Related Compound C||Not more than 0.05%|
|Related Compound D||Not more than 0.2%|
|Related Compound E||Not more than 0.2%|
|Formyl leucine||Not more than 0.2%|
|Orlistat open ring epimer||Not more than 0.2%|
|D-Leucine orlistat||Not more than 0.2%|
|Orlistat open ring amide||Not more than 0.1%|
|Individual unidentified impurity||Not more than 0.1%|
|n-Hexane||Not more than 5000ppm|
|Isopropyl ether||Not more than 5000ppm|
|Residual on ignition||Not more than 0.1%|
|Heavy Metal||Not more than 20ppm|
|Water||Not more than 0.2%|
|Assay||98.0%~101.5% (on the anhydrous, solvent-free basis)|
|Conclusion||Conform with USP35|
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